Formulation and Characterization of Novel Floating Raft Forming In-situ Gel for Delivery of BCS Class II Drugs
DOI:
https://doi.org/10.52783/jns.v14.1924Keywords:
In-situ gel, Gellan gum, albendazole, Floating, Carbapol 934PAbstract
The main objective of the research was to formulate an oral raft-forming in situ gelling system of Albendazole (ABZ) to improve gastric retention and drug release in a controlled manner and remain floating in the stomach for a prolonged time. In this study in situ gelling system was developed and optimized by a two-factor at three-level (32) factorial design. It was analyzed to study the impact of two independent variables vizGellan gum [A] and Carbapol 934 P [B] on the responses, such as floating lag time, percentage (%) water uptake at 2 h, and % drug release at 6 h and 12 h. An in vitro gelation study of the in situ gel formulation showed immediate gelation and was retained for a longer period. From the obtained results of 32 factorial designs, it was observed that all the selected factors had a significant effect on the chosen response, supporting the precision of design employed for optimization. Thus, the developed oral raft-forming in situ gelling system of ABZ can be a promising and alternate approach to enhance retention in the stomach and to attain sustained release of drug by floating, thereby augmenting the therapeutic efficacy of ABZ.
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Hani U, Rahamathulla M, Osmani RA, Begum MY, Wahab S, Ghazwani M, Fatease AA, Alamri AH, Gowda DV, Alqahtani A. Development and characterization of oral raft forming in situ gelling system of neratinib anticancer drug using 32 factorial design. Polymers. 2022 Jun 21;14(13):2520.
Peppas N, Langer R. New challenges in biomaterials. Science 1994;263:1715-20.
Pande SD, Vaidya KP, Gulhane KP. Floating drug delivery system (fdds): a new way for oral drug delivery system. Int J Pharm ClinSci 2013;3:1-13.
Nidhi D. In-situ gel: a novel approach of gastro retentive drug delivery. Asian J Pharm Sci Res 2013;3:1-14.
Plourde F, Motulsky A, Couffin-Hoarau AC, Hoarau D, Ong H, Lerour JC. The first report on the efficacy of l-alanine based In- situ-forming implants foe the long-term parenteral delivery of drugs. J Controlled Release 2005;108:433-41.
Khan AD, Meenakshi B. Floating drug delivery system: an overview. Int J PharmTech Res 2010;2:2497-505.
Miyazaki S, Endo K, Kawasaki N, Kubo W, Watanale H, AttwoodD. Oral sustained delivery of paracetamol from in situ gelling xyloglucan formulations. Drug Dev Ind Pharm 2003;29:113-9.
Modi SA, Gaikwad PD, Bankar VH, Pawar SP. Sustained release drug delivery system: a review. Int J Pharm Res Dev 2011;2:147-60.
MoinAfrasim, Shiva kumar HG. Formulation of sustained release Diltiazem matrix tablet using hydrophilic gum blends. Top J Pharm Res 2010;9:283-91.
NayakAmitkumar, MajiRuma, Das Biswarup. Gastroretentive drug delivery system: a review. Asian J Pharm Clin Res 2010;3:1-10.
Madan M, Bajaj A, Lewis S, Udapa N, Baig JA. In-situ forming polymeric drug delivery. Indian J Pharm Sci 2009;71:242-51.
Thomas LM. Formulation and evaluation of floating oral in-situgel of metronidazole. Int J Pharm PharmSci 2014;6:265-9.
Hasan MJ, Kamal BA. Formulation and evaluation of ranitidine hydrochloride are floating In situ gel. Int J Pharm PharmSci 2014;6(Suppl 2):401-5.
Shivaraju, Parthiban S, Senthilkumar SK. Preparation and evaluation of ornidazole in situ gelling system for gastro retentive drug delivery. Int J Pharm 2013;3:62-9.
Al-Mamun MA, Rahman MR, Biswas S, Kundu SK, Rayhan J. Formulation and bioequivalence evaluation of an extended release solid drug delivery system for metronidazole using usingeudragit nm30d and methocel premium K4m as retardant material. Am J Adv Drug Delivery 2014;2:39-51.
Patel DM, Patel CN. Formulation and evaluation of floating oralin-situ gelling system of amoxicillin. ISRN Pharm 2011;1:1-8.
Patel JK, Chavda JR, Modasiya Mk. Floating in-situ gel based on alginate as a carrier for stomach specific drug delivery of famotidine. Int J Pharm Sci Nanotech 2010;3:1092-104.
Choi BY, Park HJ, Hwang SJ, Park JB. Preparation of alginate boads for floating drug delivery system: effects of CO2 gas- forming agents. Int J Pharm 2002;239:81-91.
Google J, Vandrbist F, Amighi K. Development and evaluation of new multiple-unit levodopa sustained–release floating dosage forms. Int J Pharm 2007;334:35-41.
Rajinikanth PS, Mishra B. Floating in-situ gelling system for stomach site-specific delivery of clarithromycin to eradicate Helicobacter pyroli. J Controlled Release 2008;125:33-41.
Cai ZY, Galettis P, Lu Y, Morris DL, Pourgholami MH. Pharmacokinetics of albendazole in New Zealand white rabbits: oral versus intraperitoneal administration. Anticancer research. 2007 Jan 1;27(1A):417-22.
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