Formulation, Optimization, and Evaluation of Immediate-Release Tablets of Omeprazole
DOI:
https://doi.org/10.52783/jns.v14.2351Keywords:
Bioavailability, Disintegration, Dissolution, Drug Release, Excipient Selection, Formulation, Immediate-Release TabletsAbstract
This research focuses on the development and evaluation of immediate-release omeprazole tablets aimed at enhancing the therapeutic effectiveness and patient compliance in managing gastric acid-related disorders. Omeprazole, a widely used proton pump inhibitor, traditionally requires enteric coatings to prevent degradation by gastric acid, which can delay its absorption and therapeutic onset. The study explores a novel formulation that integrates sodium bicarbonate to neutralize gastric acidity and stabilize omeprazole, thereby facilitating rapid absorption. Various concentrations of sodium bicarbonate were optimized to ensure adequate neutralization while maintaining the tablet's integrity and bioavailability. In vitro dissolution studies demonstrated that the immediate-release formulation effectively protects omeprazole from acid degradation, allowing for prompt gastric pH elevation. Furthermore, pharmacokinetic evaluations indicated improved absorption profiles compared to delayed-release alternatives. The findings highlight the formulation’s potential as a flexible dosing option, providing quicker relief from symptoms of gastroesophageal reflux disease (GERD) and other acid-related conditions. This research validates the efficacy of the immediate-release formulation of omeprazole, emphasizing its significant contribution to the management of acid-related disorders.
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