Safety of Probiotic Supplementation in Preterm Infants with Gastrointestinal Surgical Conditions: A Retrospective Audit

Authors

Mohammed Abdul Hakeem Princess Margaret Hospital for children & King Edward Memorial Hospital for women Perth WA Australia
Sanjay Patole King Edward Memorial Hospital for women Perth WA Australia Centre for Neonatal Research and Education, School of Paediatrics and Child Health, University of Western Australia
Anthony Keil Head of Microbiology, Princess Margaret Hospital Subiaco Perth 6008 WA, Australia
Shripada Rao Princess Margaret Hospital for children & King Edward Memorial Hospital for women Perth WA Australia Centre for Neonatal Research and Education, School of Paediatrics and Child Health, University of Western Australia

DOI:

https://doi.org/10.52783/jns.v7.366

Keywords:

Probiotics, Preterm infant, Gastrointestinal tract, Surgery, Sepsis

Abstract

Background: Limited data exists on the safety of probiotic supplementation in preterm infants with gastrointestinal (GI) surgical conditions.

Aims: To assess the safety of Bifidobacterium breve (B. breve) M-16V supplementation in preterm in-fants with GI surgical conditions in our unit with regards to probiotic sepsis.

Methods: This retrospective audit of prospectively collected data involved screening of neonatal data-bases to identify preterm infants.

Results: Data on 33 preterm infants who underwent 43 GI surgeries and received probiotics was ana-lysed. The median (IQR) gestation at birth and postnatal age at surgery was 30 (26.8-30.7) weeks, and 5 (1-34) days respectively. Twelve (36.3%) infants received probiotics in the preoperative period, 24 (72.7%) received it in the post-operative period, and 10 (30.3%) received it both in the pre-operative and post-operative period. The median (IQR) post-operative age at commencement, duration and number of doses of probiotics was day 10 (6-13), 43 (34-56) days, and 70 (61-100) respectively. Only one infant died; the reason for death was midgut volvulus. None developed Bifidobacterial sepsis.

Conclusions: Probiotic sepsis did not occur following B. breve M-16V supplementation in our small cohort of preterm infants with GI surgical conditions. Adequately powered randomised controlled trials are needed to confirm safety and efficacy of B. breve M-16V in this cohort.

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Published

2018-01-05

How to Cite

Abdul Hakeem M, Patole S, Keil A, Rao S. Safety of Probiotic Supplementation in Preterm Infants with Gastrointestinal Surgical Conditions: A Retrospective Audit. J Neonatal Surg [Internet]. 2018Jan.5 [cited 2025Sep.12];7(1):3. Available from: https://mail.jneonatalsurg.com/index.php/jns/article/view/366

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Issue

Vol. 7 No. 1 (2018): Journal of Neonatal Surgery

Section

Original Article

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