Translational Medicine: Bridging the Gap between Laboratory Research and Clinical Practice in Public Health
Keywords:
Translational medicine, bench-to-bedside, public health, clinical application, research translation, healthcare innovationAbstract
The term of translational medicine is used for a multidisciplinary approach to accelerate the transfer of laboratory discoveries to practical clinical application leading to the increased public health outcome. It by bridging the translational gap between the sciencific advancements and patient care, so that it precisely links scientific research to diagnostics, therapies and preventive strategies. This is a multi stage process (T1–T4, bench-to-bedside research (T1) to implementation in real world populations (T4)). translational medicine has its potential, however it is hindered by regulatory limitation, lack of funding, and adaption for various aspects of scientists collaborating with clinicians and policymakers. This framework serves a large scale validation, policy consideration and community participation role in supply unto public health. Successful translational research examples, mRNA vaccines for COVID-19 and targeted cancer therapies, demonstrate the impact of translational research. Nevertheless, insufficient allocation of resource and ethical concerns need to be addressed to ensure equity of benefits. Translational medicine is explored in this paper in terms of how it makes progress in public health, and the reasons behind the lingering failure to do so. It also describes ways of improving collaboration, funding models, and policy reforms for maximising translation of research into practice. If these efforts are strengthened, translational medicine is a means to drive innovation, reduce healthcare disparities and improve global health outcomes
Downloads
Metrics
References
S. Woolf, "Translating Research into Public Health Policy," American Journal of Public Health, vol. 108, no. 10, pp. 1271–1272, Oct. 2018.
A. A. Rizvi et al., "Translational research: from bench to bedside," Mayo Clinic Proceedings: Innovations, Quality & Outcomes, vol. 2, no. 3, pp. 251–259, Sep. 2018.
K. Khoury and M. Galea, "Translational Epidemiology and Public Health Practice," American Journal of Epidemiology, vol. 187, no. 4, pp. 832–839, Apr. 2018.
J. M. Balogh, B. A. Nass, and M. P. Ganz, "Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis," National Academies Press, 2019.
M. C. Taylor and E. S. Lilford, "Accelerating Translation of Health Research into Practice," BMJ Global Health, vol. 5, no. 9, e002553, 2020.
S. A. Goldman and J. D. Phelps, "Bridging the Translational Gap: A Role for Clinical Pharmacology," Clinical Pharmacology & Therapeutics, vol. 105, no. 1, pp. 27–30, Jan. 2019.
C. J. Lomas, "Knowledge Translation: Applying the Science of Implementation," Journal of Continuing Education in the Health Professions, vol. 38, no. 2, pp. 81–85, 2018.
R. B. Altman, "Artificial Intelligence (AI) Systems for Translational Medicine," NPJ Digital Medicine, vol. 1, no. 1, 2018.
C. Holmes et al., "Translational Medicine in the Era of Big Data," Health Information Science and Systems, vol. 8, no. 1, 2020.
J. Westfall, L. Mold, and B. Fagnan, "Practice-Based Research: 'Blue Highways' on the NIH Roadmap," JAMA, vol. 321, no. 8, pp. 745–746, Feb. 2019.
M. A. Blennerhassett, "Precision Public Health: Translating Genomics to Improve Population Health," Frontiers in Public Health, vol. 7, 2019.
H. R. Jones and L. J. Greene, "Innovations in Translational Research Methodology," Translational Research, vol. 215, pp. 1–8, Jan. 2020.
R. J. Lilford, "Implementation Science: Improving Practice and Policy," Implementation Science, vol. 15, no. 1, 2020.
S. C. Wong et al., "Bridging Translational Research with Public Health Applications," Annals of Translational Medicine, vol. 8, no. 17, 2020.
K. L. Wootton, "Challenges and Successes in Translational Public Health," International Journal of Public Health, vol. 65, pp. 1721–1729, Dec. 2020.
M. B. Terry, "Translational Epidemiology: Moving Beyond Bench and Bedside," Current Epidemiology Reports, vol. 5, pp. 312–317, 2018.
L. M. Sands and J. B. Goodwin, "Optimizing Translational Medicine for Health Equity," BMC Health Services Research, vol. 21, no. 1, 2021.
A. D. Nguyen et al., "Technology-Enabled Translational Medicine and Public Health," Journal of Translational Medicine, vol. 18, no. 1, 2020.
K. R. Olson et al., "Translating Innovations in Health Care Delivery: Learning from Public Health," Healthcare, vol. 7, no. 1, 2019.
D. R. Bangash, "The Role of Biomarkers in Translational Public Health," Frontiers in Medicine, vol. 6, 2019.
F. R. Adler et al., "Precision Public Health for Infectious Disease Prevention," Nature Medicine, vol. 26, pp. 190–191, 2020.
S. J. Topol, "High-Performance Medicine: The Convergence of Human and Artificial Intelligence," Nature Medicine, vol. 25, pp. 44–56, 2019.
P. Subramaniam et al., "The Clinical and Translational Science Spectrum: Successes and Challenges," Journal of Clinical and Translational Science, vol. 4, no. 1, pp. 1–10, 2020.
J. R. Kerry et al., "Linking Laboratory Research with Community-Based Prevention Programs," American Journal of Preventive Medicine, vol. 58, no. 6, pp. 828–835, 2020.
A. N. Patel and T. G. Harris, "The Future of Translational Medicine: A Public Health Perspective," Frontiers in Public Health, vol. 9, 2021.
..
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
