Formulation, Optimization and Evaluation of Poorly Soluble Drug Snedds
Keywords:
Self nanoemulsifying drug delivery system, kaempferol, In vitro evaluation, Oral bioavailabilityAbstract
The goal of the study is to increase the oral bioavailability of kaempferol by creating a self-nanoemulsifying drug delivery system (SNEDDS). In the current work, a variety of oils, surfactants, and co-surfactants were used to manufacture kaempferol into SNEDDS. Numerous investigations, including droplet size and thermodynamic stability, drug content analysis, and in vitro drug release experiments, were conducted on the proposed formulations. The combination of Lauroglycol 90 as the oil phase, Poloxamer 188 as the surfactant, and Transcutol HP as the co-surfactant was chosen for the creation of SNEDDS of kaempferol after oils, surfactants, and cosurfactants were screened. The pseudo ternary phase diagram was used to optimise the formulation's composition. After evaluation, it was discovered that the optimised formulation had better in vitro drug release and good physical stability. When formulated as a self-nano emulsifying drug delivery system, a stable SNEDDS of kaempferol was created, and the results showed a significant improvement in the drug's dissolution, suggesting that it may improve the medication's oral solubility and bioavailability
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