Green Synthesis And Phytochemical Analysis Of A Polyherbal Formulation For Diabetes Mellitus
Keywords:
Antidiabetic Activity, Diabetes Mellitus, Ethnopharmacology, Green Synthesis, Herbal Medicine, Medicinal Plants, Phytochemical Analysis, Phytoconstituents, Polyherbal Formulation, Sustainable Therapy, Traditional Medicine, Type 2 DiabetesAbstract
Diabetes mellitus (DM) remains a pervasive metabolic disorder with significant global health implications, necessitating innovative, safe, and effective therapeutic strategies. This study explores the green synthesis and phytochemical analysis of a polyherbal formulation (PHF) designed for the management of DM. The biosynthesis of silver nanoparticles (AgNPs) utilizing the PHF underscores an eco-friendly, cost-effective approach, mitigating adverse effects associated with conventional chemical synthesis methods. Characterization techniques, including UV-Vis spectroscopy, FTIR, XRD, SEM, and EDX, confirmed the successful synthesis of AgNPs with an average size of approximately 20 nm. The phytochemical profiling revealed the presence of bioactive compounds such as flavonoids, alkaloids, and phenolic acids, known for their antidiabetic and antioxidant properties. In vivo assessment using alloxan-induced diabetic Wistar rats demonstrated significant improvements in blood glucose regulation, lipid profiles, and organ histopathology following treatment with PHF-AgNPs, surpassing standard antidiabetic drugs in efficacy at optimized dosages. These findings highlight the therapeutic potential of green synthesized polyherbal nanoparticles as a novel, sustainable, and effective intervention for diabetes management. This integrated approach combining nanotechnology with traditional herbal medicine presents a promising platform for future clinical applications and development of safer antidiabetic agents (2025)
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