Phytopharmaceutical Interventions in Neurodegenerative Disorders: Emerging Trends and Prospects
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N\AAbstract
Neurodegenerative diseases, characterized by progressive neuronal loss and dysfunction, pose significant challenges to global health. Recent advances in phytopharmaceuticals have emerged as a promising avenue for the prevention and treatment of these disorders. This review explores the current research on various plant-derived compounds, highlighting their neuroprotective effects and mechanism of action, including antioxidant, anti-inflammatory, and neurotropihic activities. We discuss specific phytochemicals such as flavonoids, phenolic acids, and alkaloids that have demonstrated efficacy in preclinical and clinical studies for conditions like Alzheimer’s, Parkinson’s, and Hungtington’s diseases. Additionally, the integration of modern approaches such as network pharmacology and herbal-based nanosystems is examined for enhancing the bioavailability and therapeutic potential of these natural products. Despite the promising findings, challenges such as limited bioavailability and standardization of herbal formulations remain. Future directions in research should focus elucidating the molecular mechanisms underlying the neuroprotective effects of phytochemicals, conducting rigorous clinical trials, and developing innovative delivery systems to optimize their therapeutic applications. By bridging traditional knowledge with contemporary scientific methodologies, phytopharmaceuticals hold the potential to significantly improve treatment outcomes for patients suffering from neurodegenerative diseases.
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Devhare, L. D., Bodhankar, S. S., Warambhe, P., Uppalwar, S. V., Devhare, D. L., Uchibagle, S., & Shende, S. (2023). Important role of food and nutritional security during Covid-19: A survey. Eur. Chem. Bull, 12(5), 1363-1374.
Gnana, R. P. M., Devhare, L. D., Dharmamoorthy, G., Khairnar, M. V., & Prasidha, R. (2023). Synthesis, Characterisation, Molecular Docking Studies and Biological Evaluation of Novel Benzothiazole Derivatives as EGFR Inhibitors for Anti-breast Cancer Agents. International Journal of Pharmaceutical Quality Assurance, 14(3), 475-480.
Prasad, M., Suman, A., Srivastava, S., & Devhare, L. D. (2023). Butea monosperma stem bark extract partially reverses high fat diet-induced obesity in rats. Eur. Chem. Bull, 12(5), 4267-4273.
Thakare, V. M., Umare, S. A., & Devhare, L. D. (2023). Separation and purification of carboxymethyl cellulose from Spinacia Oleracea for use in pharmaceutical dosage form. Eur. Chem. Bull, 12(5), 4062-4080.
Suruse, P. B., Deshmukh, A. P., Barde, L. G., Devhare, L. D., Maurya, V. K., Deva, V., & Priya, N. S. (2023). Rimegepant embedded fast dissolving films: A novel approach for enhanced migraine relief. Journal of Survey in Fisheries Sciences,10(1), 2071-2084.
Pathak, N. R., Devhare, L. D., Sawarkar, K. R., Dubey, M., Trivedi, V., Thakre, A. R., & Thakare, V. M. (2023). Aclinial reveiew on pharmacological evaluation of Thiazolidine and Isatin in the new millenium as magic moieties. Eur. Chem. Bull, 12(5), 3410-3417.
Nikam Nikita, R., Vaishnavi, A., & Lalchand, D. (2023). Parenteral drug delivery approach: an overview. Journal of xidian university, 17(1), 386-400.
Shende, S. M., Meshram, B., Karemore, H., & Devhare, L. D. (2023). Development And Characterization of Glycerogelatin Suppositories For Enhanced Efficacy. European Journal of Pharmaceutical and Medical Research, 10(6), 522-528.
Shukla, M., Tiware, S. A., Desai, S. R., Kumbhar, S. T., Khan, M. S., Mavai, Y., & Devhare, L. D. (2023). Pharmacological Evaluation of Gloriosa Superba Linn Flower Extract For Antiulcer Activity. Journal of Survey in Fisheries Sciences, 10(2), 463-470.
Tiwari, R., Mishra, J., Devhare, L. D., & Tiwari, G. (2023). AN UPDATED REVIEW ON RECENT DEVELOPMENTS AND APPLI-CATIONS OF FISH COLLAGEN. Pharma Times, 55(06), 28.
Polireddy, P., Malviya, V., Arora, S., Singh, M., pooja Tanaji, G., Devhare, L. D., & Dharmamoorthy, G. (2023). Assessment of Hepatoprotective Potential of Ecbolium Linneanum Extract on Experimental Animals. Journal of Coastal Life Medicine, 11, 884-890.
Devhare, L. D., Kumbhar, S. T., Chitrapu, P., Kundral, S., & Borkar, A. A. (2023). In-Silico Molecular Docking Study of Substituted Imidazo 1, 3, 4 Thiadiazole Derivatives: Synthesis, Characterization, and Investigation of their Anti-Cancer Activity. Journal of Coastal Life Medicine, 11, 1237-1245.
Sonule, M., Devhare, L. D., Babu, M. N., Gunjal, S. D., & Varalaxmi, S. (2023). Microemulgel-based Hydrogel of Diclofenac Sodium using Lipidium sativum as a Gelling Agent. International Journal of Drug Delivery Technology, 13(4), 1235-1239.
Shriram, B. K., Devhare, L. D., Mehrotra, A., Deokar, S. S., & Singh, S. P. (2023). Formulation and Evaluation of Mosquito Repellent Stick. International Journal of Drug Delivery Technology, 13(4), 1283-1286.
Tiwari, G., Gupta, M., Devhare, L. D., & Tiwari, R. (2024). Therapeutic and phytochemical properties of thymoquinone derived from Nigella sativa. Current Drug Research Reviews Formerly: Current Drug Abuse Reviews, 16(2), 145-156.
Singh, M., Malik, A., Devhare, D. L., Ruikar, D. B., Krishnan, K., Kumar, D. V., & Devnani, D. (2023). Comparative Case Study On Tuberculosis Patients Between Rural And Urban Areas. Journal of Survey in Fisheries Sciences, 10(2), 1-11.
Thakre, S. M., Kumar, D. V., Ahuja, A., Hamid, N., Thakre, A. R., Khan, M. S., & Devhare, L. (2023). Exploring the Influence of an Antifungal Medication on Patients Receiving Oral Hypoglycemic Therapy: Investigating the Interplay Between Medications. Journal of Coastal Life Medicine, 11, 1255-1262.
Adimulapu, A. K., Devhare, L. D., Patil, A., Chachda, N. O., & Dharmamoorthy, G. (2023). Design and Development of Novel Mini Tablet Cap Technology for the Treatment of Cardiovascular Diseases. International Journal of Drug Delivery. Technology, 13(3), 801-806.
Krishna, K. V., Jain, P. K., Devhare, L. D., Sharma, R. K., Bagade, O. M., Venkatesham, A., & Yogesh, P. K. (2023). A Study on Antidiabetic Potential of Dried Fruits Extract of Eucalyptus Globulus in Experimental Animals. Journal of Biomedical Engineering, 40(3), 99-110.
Priya, M. G. R., Prasanth, L. M. L., Devhare, L. D., Yazdan, S. K., & Gunjal, S. (2024). Synthesis, DNA Binding, Molecular Docking and Anticancer Studies of Copper (II), Nickel (II), and Zinc (II) Complexes of Primaquine-based Ligand. International Journal of Pharmaceutical Quality Assurance, 15(1), 69-75.
Choudhary, R. K., Beeraka, S., Sarkar, B. K., Dharmamoorthy, G., & Devhare, L. (2024). Optimizing Verapamil Hydrochloride In-situ Delivery: A Strategic Formulation Approach using Box-Behnken Design for Enhanced Performance and Comprehensive Evaluation of Formulation Parameters. International Journal of Drug Delivery Technology, 14(1), 61-70.
Kumar, K. K., Kiran, V., Choudhary, R. K., Devhare, L. D., & Gunjal, S. D. (2024). Design Development and Characterization of Nicardipine Solid Lipid Nano-Particulars. International Journal of Drug Delivery Technology, 14(1), 71-78.
Devhare, L. D., & Gokhale, N. (2023). Extraction. Phytochemical Screening and Comparative Pharmacological Evaluation of Some Indigenous Plants for Antiulcer Activity, 01-244.
Devhare, L. D., Naikwadi, A. S., & Arote, S. B. (2023). Aditya V, Hiteshkumar S. Agrawal. Pharmacy Practice. Pritam Publication, 1-200.
Devhare, L. D., & Nikam, N. (2023). Practical Handbook of Pharmacology-II. Pritam Publication, 1, 1-95.
Devhare, L., & Prasad, C. (2024). Prophylactic and curative activity of Withania somnifera on experimentally induced calcium oxalate nephrolithiasis. Journal of medical pharmaceutical and allied sciences, 13(4), 6687-6695.
Shende, S., Devhare, L., Prasad, C., Khobragade, A., & Khapne, A. (2024). Next-Generation Drug Delivery Strategies for Personalized Healthcare. Pharmaceutical Research - Recent Advances and Trends, 2, 28-62
Devnani, D., Prasad, K. K., Bongade, K., Verma, A., Choudhary, T., Posa, M. K., & Devhare, D. L. (2024). Case Study On Rubella Virus. Journal of Advanced Zoology, 45(2). 1133
Lalchand D. Devhare, Ram Kumar Choudhary, Kiran Kumar Kurella, Falgunee Dasharath Ghadi, Jyoti Mundlia, Murali Krishna Kandukuri. (2024). Research Methodology and Biostatistics.IIP Publication.1-165
Kumar, Y. G., Dharmamoorthy, G., Devhare, L. D., Gunjal, S. D., & Deshpande, M. (2023). Toxicity Profile Study of Antihypertensive Drug Prazosin in Pregnant Wistar Rats. Journal of Advanced Zoology, 44, 64
Devhare, L. D.(2023) Extraction phytochemical screening and comparative pharmacological evaluation of some indigenous plants for antiulcer activity.Shodhganga.1-244
Konda V V S Krishna, Virendra Kumar Maurya, S. R. Fulmali, Praful N Giradkar, Lalchand D. Devhare (2023). A Textbook of Social and Preventive Pharmacy. Pritam Publication.1-201
Konda V V S Krishna, Amruta R. Patil, Anupama A. Kapadnis, Vinod M. Thakare, Lalchand D. Devhare. (2023). Textbook of Pharmacotherapeutics. Pritam Publication.1-166
Savita Shrikant Deokar Vedanshu R. Malviya, Biresh Kumar Sarkar, Lalchand D Devhare, Mangla Nand Singh.(2023). A Textbook of Novel Drug Delivery System. IIP Publication.1-230.
Chand, G., Devhare, L. D., & Hooda, T. (2024). Diverse Properties of Tinospora Cordifolia (Giloy, Heart Leaved Moonseed) world wild use for immunotherapies;boosting the body’s defence and immune support . Emerging Paradigms for Antibiotic-Resistant Infections: Beyond the Pill. Sringer Nature. 471-486
Upreti, P., Devhare, L. D., Abdulmageed, L. H., Kumar, Y. G., Kumar, R., & Dharmamoorthy, G. (2024). Combatting Antibiotic Resistance: Leveraging Fecal Microbial transplantation for gut health. Emerging Paradigms for Antibiotic-Resistant Infections: Beyond the Pill. 211-232.
Chandani Prasad, Lalchand Devhare, Ashish Khobragade and Shubham Shende. (2025). Herbal Approaches To Skin Lightening: A Comprehensive Review. 16(1): 62-68.
Vyas S, Anitha KN, Mudduluru NB, Devhare LD. Quality by Design Approach to Nasal Mucoadhesive Microspheres: Enhanced Sumatriptan Succinate Delivery through Formulation and Characterization. International Journal of Drug Delivery Technology. 2024;14(3):1644-1651
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